Lobular Breast Cancer Gene Project


Lobular breast cancer accounts for about 1 in 10 cases of the disease and begins in the milk glands, however very little is known about why this particular type of breast cancer develops. One thing that is clear that this form of the disease can be passed down through family members.


Lobular Breast Cancer Gene Prevent Breast Cancer Charity UK

Finding the genes which increase the risk of Lobular Breast Cancer


Our researchers are currently undertaking ‘whole genome sequencing’, a method which can screen all 25,000 genes in the human genome at once, in order to identify the genetic anomalies that increase the risk of lobular breast cancer. Edinburgh University will undertake the whole genome sequencing process, supported by The Scottish Genomes Project. Our researchers have identified 211 breast cancer samples from people under the age of 60 who have inherited this form of the disease and who also do not have any of the common genetic mutations which increase cancer risk (i.e. BRCA1, BRCA2 and CDH1).


By identifying the genes that cause lobular breast cancer, we hope that in the future it will be possible to personalise the screening process for this cancer, reassure at-risk relatives, and provide a starting point to develop specific treatments for this type of cancer.


If you would like more information about this project, please download our project information sheet by clicking here or downloading it on the right hand side of the page.


To donate to projects such as this one, please click here and pick Gene Research from the list of drop down options.